| Wednesday, September 22, 2021 |
| Metz |
1 - 2 |
Paris Saint-Germain |
| Lyon |
3 - 1 |
ESTAC |
| Lorient |
1 - 0 |
OGC Nice |
| Lens |
0 - 1 |
Strasbourg |
| Angers |
0 - 0 |
Marseille |
| Stade Rennais FC |
6 - 0 |
Clermont |
| Nantes |
3 - 1 |
Brest |
| Montpellier Hérault SC |
3 - 3 |
Girondins de Bordeaux |
| Monaco |
3 - 1 |
Saint-Etienne |
| LOSC Lille Métropole |
2 - 1 |
Stade de Reims |
| Sunday, September 19, 2021 |
| Paris Saint-Germain |
2 - 1 |
Lyon |
| Marseille |
2 - 0 |
Stade Rennais FC |
| Angers |
1 - 4 |
Nantes |
| ESTAC |
1 - 1 |
Montpellier Hérault SC |
| Stade de Reims |
0 - 0 |
Lorient |
| Clermont |
1 - 1 |
Brest |
| OGC Nice |
2 - 2 |
Monaco |
| Saturday, September 18, 2021 |
| Saint-Etienne |
1 - 2 |
Girondins de Bordeaux |
| Lens |
1 - 0 |
LOSC Lille Métropole |
| Friday, September 17, 2021 |
| Strasbourg |
3 - 0 |
Metz |
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